An investigation was carried out at Horticultural Instructional Farm, Chimanbhai Patel College of Agriculture, Sardarkrushinagar during 2019-20. Results revealed that the Spinosad 45 SC (0.036%) was found to be the most effective against pomegranate thrips, followed by Cyantraniliprole 10.26 OD (0.0072%) and Clothianidin 50 WDG (0.025%). While for the management of pomegranate aphid Clothianidin 50 WDG @ (0.025%) gave excellent results, followed by Cyantraniliprole 10.26 OD (0.0072%). While, Dinotefuran 20 SG (0.0055%) was found least effective treatment against sucking pests of pomegranate. Whereas, effect of newer molecules on natural enemies revealed that, Cyantraniliprole 10.26 OD (0.0072%) was the safest insecticide on coccinellids, followed by Spinosad 45 SC (0.036%), whereas, Thiamethoxam 25 WG (0.0084%) had the most harmful effect to the coccinellids in pomegranate. In case of chrysopids, Cyantraniliprole 10.26 OD (0.0072%) and Spinosad 45 SC (0.036%) were proved to be the least harmful treatments, whereas, Thiamethoxam 25 WG (0.0084%) and Clothianidin 50 WDG (0.025%) had the detrimental effect to the chrysopids in pomegranate eco-system.