The ethno-botanico-medicinal knowledge of Ao Naga tribe was gathered through interviews using a standard, pre-structured, validated questionnaire so-liciting the local name, plant part/s used, name of the illness being treated, drug preparation and dosage. The study helped to document 16 Angiosperm species as anticancer plants from 12 families, comprising seven trees, eight herbs and one shrub. Traditional treatments are accessible to the loal peoople for seven types of cancer, namely blood, breast, gall bladder, liver, lungs, mouth and stomach. The highest used plant part was fruits (31.25%), followed by leaves (25%) and rhizomes (18.75%). The Relative Frequency of Citation value ranges from 0.45 to 0.97. The family-use value was recorded as highest for Zingiberaceae. The 100% fidelity level was found for Curcuma caesia, Garcinia peduncu-lata, Myrica rubra, Picria fel-terrae and Rhus chinensis. The recorded data gathered may be useful for further research in the area of pharmacology in the context of novel drug development.