A field experiment was conducted during rabi, 2019-20 to 2021-22 to evaluate different botanicals and bio-pesticides against aphid, Aphis gossypii Glover infesting isabgol at Seed Spices Research Station, S. D. Agricultural University, Jagudan (Gujarat). Among them, neem leaf extract 10% was proved to be the most effective insecticide (3.28) for the management of isabgol aphid and it was followed by the treatments of Beauveria bassiana 1.15 WP, Lecanicillium lecanii 1.15 WP, custard apple leaf extract 10%, garlic bulb extract 5% and ipomoea leaf extract 10%, respectively. Neem leaf extract 10% had obtained the highest seed yield of isabgol (511 kg/ha), but it was statistically at par with Beauveria bassiana 1.15 WP (476 kg/ha), Lecanicillium lecanii 1.15 WP (457 kg/ha) and garlic bulb extract 5% (439 kg/ha).