There is vast expanse of ethnomedicinal heritage in north eastern region of India for bioprospecting of the green medicine based on ethno therapeutics practised among the local tribals, healers for meeting health care and promotion of health.The tribals like Mikir, Naga, Manipuri, Apatani, Garo etc. collect many plants and plant produce for treatment of various diseases and disorders in their community from the ambient vegetation. The present paper highlights some of the important species of ethnomedicinal value used by the tribal healers for treating diseases and disorders like malarial fever, diarrhoea and dysentery, skin diseases, jaundice, arthritis, venereal diseases etc. Based on the locally available herbal wealth, there is enormous scope for commercial cultivation of some useful herbs and production of safe green medicines by establishing plant based industries in the tribal tracts for the ecodevelopment and sustainable utilisation of medicinal plant genetic diversity and their conservation for the human welfare.