The green synthesis of silver nanoparticles (AgNPs) is a simple, environmentally beneficial and valuable alternative to the physicochemical synthesis method. This study aimed to produce AgNPs from a silver nitrate solution by using Piper betle leaf extract as a reducing agent. The UV-Visible spectroscopy, X-ray diffraction, Fourier Transform Infrared Spectroscopy, and Scanning Electron Microscopy with Energy Dispersive X-ray analysis were employed to determine the physicochemical characteristics of AgNPs produced. The antiinflammatory and antioxidant properties of AgNPs were tested using the albumin denaturation method and the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, respectively. The test results showed that the AgNPs were spheroidal in the range of 80–180 nm and of crystalline nature; they showed good antioxidant and anti-inflammatory properties. The green synthesized silver nanoparticles from Piper betle and therefore, can be used as a wound healing agent.