The phytochemical investigation of leaves of Solanum erianthum D.Don (Solanaceae) in 70% ethanol revealed the presence of 38.87% carbohydrates, 35.61% proteins, and rest are fatty acids, lipids and vitamins. Amongst the fatty acids, monounsaturated are prominent (43.16%) followed by Cis-11 eicosenoic acid (35.03%) and polyunsaturated fatty acids (30.62%). The vitamin estimation with RP-HPLC showed the highest content of vitamin C (34.50 mg/100g). The FTIR assay confirmed the presence of alkyl, aldehydic and methyl groups mainly in the leaves. S. erianthum leaves are a rich source of phytoconstituents which can be therapeu-tically used in herbal medicines when tested for their efficacy.