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1. HISTORY OF MEDICAL MICROBIOLOGY
1.1. MICROORGANISMS AND DISEASE
1.2. DEVELOPMENT OF PURE CULTURE
1.3. VIRUSES AS HUMAN PATHOGEN
1.4. SOURCES AND SPREAD OF INFECTION
1.5. IMMUNITY AND IMMUNIZATION
1.6. FUTURE
1.7. FURTHER READING
2.NORMAL MICROBIAL FLORA OF HUMAN BODY
2.1. INTRODUCTION
2.2. STATUS OF MICROFLORA IN HUMAN BODY
2.3. TYPES OF MICROFLORA
2.3.1 Microflora Associated with the Skin
2.3.2 Normal Microflora of Eye
2.3.3 Normal Micro Flora of the Respiratory Tract
2.3.4 Normal Micro Flora of Mouth
2.3.5 Normal Micro Flora Associated with Teeth
2.3.6 Normal Microflora of External Ear
2.3.7 Normal Microflora Associated with Gastrointestinal Tract
2.3.8 Genitourinary Tract
2.4. FURTHER READING
3.HOST DEFENCE
3.1 DEFINITION OF DISEASE
3.2 NON-SPECIFIC DEFENCE MECHANISM
3.2.1 Mechanical Barriers
3.2.2 Classes of PRPs
3.2.3 Formation of Reactive Oxygen Intermediates (ROIs)
3.2.4 Reactive Nitrogen Intermediates (RNIS)
3.3 FURTHER READING
4.HOST-PATHOGEN INTERACTIONS
4.1 INTRODUCTION
4.2 BACTERIAL TOXINS
4.2.1 Exotoxins
4.2.2 Endotoxins
4.3 VIRULENCE
4.4 ATTENUATION
4.5 FURTHER READING
5.GENERAL PRINCIPLES OF DIAGNOSTIC MICROBIOLOGY
5.1 INTRODUCTION
5.2 SPECIMENS
5.3 COLLECTION
5.4 TRANSPORT
5.5 PROCESSING
5.5.1 Microscopic Examination of the Specimen
5.3.2 Culture Media
5.5.3 Culture
5.5.4 Viral Isolation using Tissue Culture Methods
5.6 SEROLOGICAL TESTS
5.6.1 Specificity and Sensitivity
5.7 MOLECULAR METHODS
5.8 BLOOD GROUPS
5.8.1 ABO Blood Groups
5.8.2 Rh Blood Groups
5.9 BIOCHEMICAL METHODS
5.10 FURTHER READING
6.CHEMOTHERAPY AND ANTIMICROBIALS
6.1 INTRODUCTION
6.2 CHEMOTHERAPEUTIC AGENTS
6.2.1 Penicillins
6.2.2 Cephalosporins
6.2.3 Aminoglycosides
6.2.4 Tetracyclines
6.2.5 Quinolones
6.2.6 Vancomycin
6.2.7 Teicoplanin
6.2.8 Chloramphenicol
6.2.9 Erythromycin
6.3 SULPHA DRUGS
6.3.1 Structure
6.3.2 Mechanism of Action
6.3.3 Clinical Use
6.4 ANTIVIRAL AGENTS
6.4.1 Interferon (IFN)
6.4.2 Amantadine
6.4.3 Base Analogues
6.4.4 Acyclovir (ACV)
6.4.5 Ribavirin
6.4.6 Azidothymidine (AZT)
6.4.7 Ganciclovir (GCV)
6.4.8 Adenine Arabinoside (AraA)
6.4.9 Lamivudine
6.4.10 Dideoxycytidine
6.4.11 Dideoxyinosine
6.4.12 Other Nucleoside Analogues
6.5 ANTIFUNGAL ANTIBIOTICS
6.6 DRUG RESISTANCE
6.6.1 Origin of Drug Resistance and its Transmission
6.7 FURTHER READING
7.SUSCEPTIBILITY TESTS
7.1 INTRODUCTION
7.2 FURTHER READING
8.PREVENTIVE CONTROL OF DISEASES
8.1 INTRODUCTION
8.2 ACTIVE AND PASSIVE IMMUNIZATION
8.2.1 Passive Immunization
8.2.2 Active Immunization
8.3 VACCINES – NATURAL AND RECOMBINANT
8.3.1 Natural Vaccines
8.3.2 Recombinant Vaccines
8.4 FURTHER READING
9.DISEASES OF MAN
9.1 AIR-BORNE DISEASE
9.1.1 Tuberculosis
9.1.2 Influenza
9.2 FOOD AND WATER-BORNE DISEASES
9.2.1 Cholera
9.2.2 Typhoid
9.2.3 Hepatitis-A
9.2.4 Poliomyelitis
9.2.5 Amoebiasis
9.3 INSECT-BORNE DISEASES
9.3.1 Malaria
9.3.2 Filariasis
9.3.3 Dengue Fever
9.4 CONTACT DISEASES
9.4.1 Syphilis
9.4.2 Gonorrhoea
9.5 ZOONOTIC DISEASES
9.5.1 Rabies
9.5.2 Anthrax
9.6 BLOOD-BORNE DISEASES
9.6.1 Serum Hepatitis
9.6.2 AIDS
9.7 NOSOCOMIAL INFECTIONS
9.7.1 Hospital Environmental Factors Promoting Nosocomial Infections
9.7.2 Sources
9.7.3 Nosocomial Pathogens
9.7.4 Prevention and Control
9.8 FURTHER READING
10.HISTORY AND DEVELOPMENT OF IMMUNOLOGY
10.1 DEVELOPMENT OF VACCINATION
10.2 DISCOVERY OF HUMORAL IMMUNITY
10.3 IMMUNITY AGAINST NON-PATHOGENIC SUBSTRATES
10.4 SELECTIVE THEORY
10.5 STRUCTURE OF AN ANTIBODY
10.6 SOMATIC HYBRIDIZATION
10.7 SCOPE OF IMMUNITY
10.8 FURTHER READING
11.SCOPE OF IMMUNITY
11.1 INTRODUCTION
11.2 TYPES OF IMMUNITY
11.3 ORGANS OF IMMUNE SYSTEM
11.3.1 Primary Lymphoid Organs and Tissue
11.3.2 Secondary Lymphoid Organs and Tissues
11.4 CELLS OF IMMUNE SYSTEM
11.4.1. Lymphocytes
11.4.2 Monocytes and Macrophages
11.5 FURTHER READING
12.PRINCIPLES OF IMMUNOLOGY
12.1 INTRODUCTION
12.1.1 Antigens
12.1.2 Haptens
12.2 FACTORS AFFECTING ANTIGENICITY
12.3 ANTIBODIES
12.3.1 Structure of Antibody (Ig)
12.3.2 Classes of Ig
12.4 FURTHER READING
13.POLYCLONAL AND MONOCLONAL ANTIBODIES
13.1 PRODUCTION AND APPLICATION
13.1.1 Polyclonal Antibodies
13.1.2 Monoclonal Antibodies
13.2 MONOCLONAL ANTIBODIES AND HYBRIDOMAS
13.2.1 Diagnostic and Therapeutic Uses
13.3 FURTHER READING
14.IMMUNE DISORDERS – HYPERSENSITIVITY
14.1 IMMUNE DISORDERS
14.1.1 Hypersensitivity
14.1.2 Autoimmunity and its Significance
14.2 FURTHER READING
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