The information on poisonous seeds of indigenous plant species is very much useful not only for promoting awareness among the people to avoid from harmful effects but also for judicious utilization of such seeds for control of insect-pests, bugs, mosquitoes and many injurious organisms. Very occasional references were made with regard to the poisonous nature of seeds of wild plants growing in the state or country. Therefore, attempts were made to identify the poisonous seeds of some selected plant species of Gandhamardan hill ranges of Orissa with their local name, locality of collection, distribution and notes on poisonous action.